September 13, 2025

Photobiomodulation in Ophthalmology: A Comprehensive Review of Bench-to-Bedside Research and Clinical Integration. Garg et al, 2024

Condition focus: Retinal Health, Dry Eye Disease, Corneal Recovery & Ocular Surface Metabolism:

PBM has emerged as a promising modality in ophthalmology due to its potential benefits in managing various ocular conditions. For retinal diseases, PBM has shown promise in reducing inflammation, enhancing retinal cell survival, and improving visual function. In treating corneal and anterior segment disorders, PBM accelerates wound healing, alleviates dry eye symptoms, and potentially minimizes complications following refractive surgeries. The non-invasive nature of PBM, along with its ability to modulate inflammatory responses and expedite tissue repair, positions it as a valuable adjunctive therapy in ophthalmic care. Its integration into ophthalmic practice reflects a shift toward minimally invasive, drug-free treatments that can complement traditional therapeutic approaches. As the field of ophthalmology advances toward personalized and precision medicine, PBM’s ability to target specific cellular pathways and enhance treatment outcomes underscores its relevance and potential in modern ophthalmic care.

WaveFront Alignment: The Spectral WaveFront’s dual-wavelength design (670 nm + 810 nm) aligns with the mitochondrial and anti-inflammatory mechanisms described in this review. Its ocular-specific geometry is consistent with the retinal, ocular surface, and corneal pathways outlined by Garg et al., enabling a gentle, non-thermal approach to supporting cellular resilience and tear-film physiology.

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Editor’s note: Garg et al. 2024 summarize photobiomodulation across retinal and ocular surface applications, highlighting mitochondrial and inflammatory pathways directly relevant to the Spectral WaveFront’s 670 nm and 810 nm wavelengths. For comparison of dosing windows and ocular-specific geometry, see our WaveFront Evidence Alignment. Complementary dry eye and MGD PBM findings appear in Antwi 2024, and foundational multi-wavelength mechanistic insights are detailed in Goo 2023.

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