Condition focus: Anterior Segment Inflammation & Iridocyclitis
Acute iridocyclitis represents a sight-threatening inflammatory condition of the anterior uveal tract requiring prompt intervention to prevent complications including posterior synechiae, cataract formation, and vision loss. This clinical study evaluated helium-neon (He-Ne) laser photobiomodulation as an adjunct therapy for acute iridocyclitis treatment. Patients with acute iridocyclitis received standard anti-inflammatory therapy combined with He-Ne laser treatment (632.8 nm) or standard therapy alone, with outcomes including inflammation resolution time, pain reduction, and complication rates.
Patients receiving combined He-Ne laser therapy demonstrated significantly faster resolution of anterior chamber inflammation and reduced pain compared to controls receiving standard therapy alone. The laser-treated group showed accelerated mydriasis recovery and reduced incidence of posterior synechiae formation. Treatment was well-tolerated with no adverse effects. The findings suggest that 632.8 nm He-Ne laser photobiomodulation enhances anti-inflammatory treatment efficacy in acute iridocyclitis through local anti-inflammatory effects and improved tissue healing, offering a safe adjunctive approach to reduce treatment duration and complication risk.
WaveFront Alignment:
Koev’s demonstration of red-light anti-inflammatory effects in anterior segment inflammation provides evidence for photobiomodulation’s therapeutic potential across ocular tissues, supporting the Spectral WaveFront’s multi-wavelength approach for inflammatory conditions affecting both anterior and posterior segments.
Read full article here
Editor’s note: Koev 2010 demonstrates He-Ne laser efficacy in acute iridocyclitis. For related corneal applications, see Koev 2011. Broader anti-inflammatory mechanisms appear in Goo 2023. For retinal inflammation evidence, see Kokkinopoulos 2013 and Begum 2013.
Related Articles
- He-Ne Laser for Corneal Trauma Treatment – Koev 2011
- Anti-Inflammatory Effect of Multi-Wavelength LED – Goo 2023
- Age-Related Inflammation Reduced by 670 nm – Kokkinopoulos 2013
- 670nm Light Reduces Inflammation via Cytochrome c Oxidase – Begum 2013
- PBM in Ophthalmology: Comprehensive Review – Garg 2024
Key Takeaways
- He-Ne laser (632.8 nm) as adjunct therapy significantly accelerated inflammation resolution in acute iridocyclitis
- Combined treatment reduced pain and posterior synechiae formation versus standard therapy alone
- Faster mydriasis recovery and shortened treatment duration in laser-treated group
- Well-tolerated with no adverse effects, demonstrating safety for anterior segment inflammation
Study Overview
| Study Type: | Clinical study (adjunctive therapy) |
| Wavelength(s): | 632.8 nm (He-Ne laser) |
| Treatment Protocol: | Low-level laser therapy combined with standard anti-inflammatory treatment |
| Sample Size: | Patients with acute iridocyclitis |
| Primary Outcome: | Accelerated inflammation resolution and reduced complications versus controls |
Full Citation
Koev K, et al. (2010). He-Ne low-level laser therapeutic applications for treatment of acute iridocyclitis. Acta Medica Bulgarica, 37(1):32-36. View Publication
