Condition focus: Dry Eye Disease & Meibomian Gland Dysfunction (MGD):
LLLT was conducted on patients at Dankook University Hospital upon the scheduled visits of each patient. Light irradiation was performed with a LED-based array matrix module with 5 planar panels. For the first 1 min of irradiation a wavelength of 590 nm in continuous wave and an irradiance of ≈ 50 µW/cm2 scanned panel by panel for 1 s per panel, giving a fluence of ≈ 50 µJ/cm2. At the end of that minute, 830 nm was delivered from all 5 panels at an irradiance of 100 mW/cm2 for 10 min in continuous wave mode. The system is LED-based, and the irradiance was below the ANSI values for maximum permissible exposure (MPE). The energy density over the entire near field area (encompassing the entire face and orbital area) was therefore ≈ 60 J/cm2 per session (HEALITE II, Lutronic, Goyang, Korea), with a distance between the treatment head and target tissue of approximately 17 cm.
Reports have suggested that the above parameters with the 830 nm LED-based approach have been safe and effective in general for wound healing and as an adjunctive approach to other aesthetic procedures. Specifically, the same device as used in the present study has been proven safe and effective for treating wounds on the face around the orbit, which incidentally included irradiation of the closed eyes, and for effective and safe treatment of acute herpes zoster ophthalmicus which would obviously include the orbital area16. Taken in conjunction with existing literature on the treatment of dry eye, the parameters in the current study were selected.
No serious adverse events were observed. The use of LED-LLLT for the treatment of dry eye and MGD appears to be safe and beneficial.
WaveFront Alignment: Park et al. used a 590→830 nm sequence at slightly higher diffuse fluence, the outcomes align with PBM’s known mitochondrial and inflammatory pathways. The Spectral WaveFront uses 670 nm and 810 nm with ocular-specific geometry and lower, non-contact fluence—supporting similar biologic mechanisms relevant to dry eye, eyelid-margin metabolism, and tear-film stability.
Original article link is here
Editor’s note: Park et al. 2022 provide controlled human data demonstrating that LED-based PBM can support signs and symptoms of dry eye and MGD. For comparison with the Spectral WaveFront’s wavelength selection, ocular-specific delivery, and non-thermal energy windows, see our WaveFront Evidence Alignment . Complementary PBM dry eye findings are described in Antwi 2024 , and mechanistic multi-wavelength effects in Goo 2023 . Earlier mitochondrial anti-inflammatory pathways relevant to PBM were detailed in Begum 2013 .
